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Probabilistic model of the human protein-protein interaction network

Article Abstract:

A study demonstrates a probabilistic analysis integrating model that provides a comprehensive framework for exploring the human protein interaction network. The accuracy of the predictive model is validated on an independent test of known interactions and two predicted interactions relevant to human cancer are experimentally confirmed, implicating uncharacterized proteins into definitive pathways.

Author: Pandey, Akhilesh, Ghosh, Debashis, Varambally, Sooryanarayana, Chinnaiyan, Arul M., Rhodes, Daniel R., Tomlins, Scott A., Mahavisno, Vasudeva, Barrette, Terrence, Kalyana-Sundaram, Shanker
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
HEALTH SERVICES, Cancer Therapy, Ambulatory Health Care Services, Methods, Analysis, Cancer, Cancer treatment, Cancer genetics, Protein binding, Probabilism

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The HUPO PSI's molecular interaction format-a community standard for the representation of protein interaction data

Article Abstract:

Description of the protein interaction network underlying cell physiology is a major goal of proteomics. A community standard data model is proposed for the representation and exchange of protein interaction data and members of Proteomics Standards Initiative (PSI), a work group of the Human Proteome Organization (HUPO) and others, have jointly developed this model.

Author: Brazma, Alvis, Steipe, Boris, Eisenberg, David, Xenarios, Ioannis, Pandey, Akhilesh, Moore, Susan, Bork, Peer, Poux, Sylvain, Vidal, Marc, Sherman, David, Sander, Chris, Lappe, Michael, Hermjakob, Henning, Sarkans, Ugis, Zeng, Rong, Jacq, Bernard, Montecchi-Palazzi, Luisa, Bader, Gary, Wojcik, Jerome, Salwinski, Lukasz, Ceol, Arnaud, Orchard, Sandra, Mering, Christian von, Roechert, Bernd, Jung, Eva, Mersch, Henning, Kersey, Paul, Li, Yixue, Rana, Debashis, Nikolski, Macha, Husi, Holger, Brun, Christine, Shanker, K, Grant, Seth G N, Zhu, Weimin, Legrain, Pierre, Cesarein, Gianni, Hogue, Chris, Apweiler, Rolf
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
Product development, Case studies, Cell physiology, Proteomics

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Proteomics to study genes and genomes

Article Abstract:

Proteomics, the extensive analysis of proteins, will contribute greatly to our understanding of gene function in the post-genomic era.

Author: Pandey, Akhilesh, Mann, Mattias
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
Biological Product (except Diagnostic) Manufacturing, Drugs, Deoxyribonucleic Acid, Protein, DNA, Proteins, Human nutrition

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Subjects list: Research, United States
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