Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction

Article Abstract:

The erbB/HER family of transmembrane receptor tyrosine kinases (RTKs) mediates cellular responses to epidermal growth factor (EGF) and related ligands that includes the processes such as DNA replication and division. The EGF-QDs (Quantum dots) are demonstrated as highly specific and potent in the binding and activation of the EGF receptor (erb1) rapidly internalized to exhibit active trafficking and extensive fusion.

Quantum theory, Quantum mechanics, Tyrosine metabolism

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Rescue and propagation of fully retargeted oncolytic measles viruses

Article Abstract:

A pseudoreceptor system that allows rescue and propagation of fully retargeted measles viruses displaying single-chain antibody fragments is developed. When administered intratumorally or intravenously to mice bearing human CD38 or epidermal growth factor receptor (EGFR)-positive human tumor xenografts, the targeted viruses demonstrated specific receptor-mediated anti-tumor activity.

Xenotransplantation, Measles virus

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FRET imaging

Article Abstract:

This article discusses improvements to the Forster (or Fluorescence) Resonance Energy Transfer (FRET) optical imaging technique for studying single molecules to live cells. The enhanced technique can be applied to optical sections for analyzing contributions from the components of complex molecular systems. The resolution of the technique is in the 1-10 nanometer range.

Germany, Facilities & equipment, Argentina, Methods, Equipment and supplies, Cells (Biology), Cells, Molecules, Fluorescence spectroscopy, Imaging

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