Problem solving for tumor immunotherapy

Article Abstract:

Research on tumor cell immunotherapy reveal that the tumor-destroying (CD8+) cytotoxic T lymphocytes are able to recognize the antigens expressed by tumor cells. Immunotherapy must be able to induce better responses in cancer patients who are have a low T-cell response rate.

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Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy

Article Abstract:

The authors report that they have constructed an adenovirus containing a novel regulatory circuit. Replicating adenoviruses may prove to be effective ainticanccer agents if they can be engineered to selectively destroy tumor cells.

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Signal transduction inhibitors-a work in progress

Article Abstract:

The fundamental role of kinases in cancer biology and the success of pioneering therapeutics have prompted intensive efforts to develop kinase inhibitors. The poor interplay between academics, clinicians, regulators and companies have resulted in a dismal record of development of molecularly targeted drugs.

Research, Cancer, Cellular signal transduction, Protein kinases, Oncology, Experimental

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