siRNAs: Application in functional genomics and potential as therapeutics

Article Abstract:

The small interfering RNA (siRNA) approach for gene silencing holds a great therapeutic promise as siRNAs, like micro RNA (miRNA) are used by cells to regulate gene expression and are non toxic and highly effective. But the potential drawback of using siRNAs for therapeutic is that if used in long term, siRNAs can out-compete the function of endogenous miRNA genes in certain cell types.

United States, Genetic research, RNA interference

---

Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

Article Abstract:

A modified protocol to create induced pluripotent stem (iPS) cells without using Myc retrovirus transcription factor from human or mouse is described.

DNA binding proteins, Retroviruses, Stem cell research

---

A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse

Article Abstract:

A Cre-dependent genetic switch was developed which will allow genetic modifications in transgenic mice.

Germany, France, Genetically modified mice

Similar abstracts:

• Abstracts: Relationship banking, liquidity, and investment in the German industrialization. Syndicate size, spreads, and market power during the introduction of shelf registration
• Abstracts: Assessing organizational fitness on a dynamic landscape: an empirical test of the relative inertia thesis. Hospital PR: making the news you want with what you have got
• Abstracts: Proteomics takes stem cell analyses to another level. On the road to therapeutic cloning. Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.