Dynamics competition between catch and slip bonds in selectins bound to ligands

Article Abstract:

The two-state BT model, that considers the possibility of redistribution of population from the force-free bound state to the force stabilized bound state, is used to investigate the energy landscape underlying the catch-slip transition. The model correctly predicts the absence of catch bonds in the binding dynamics of antibodies to selectins and is used to solve to energy landscape parameters characterizing adhesive interactions of P- and L-selectin complexes with sPSGL-I and endoglycan and the antibody DREG56.

Protein binding, Ligands (Biochemistry), Cell adhesion, Structure, Report

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Time scales for the formation of the most probable tertiary contacts in proteins with applications to Cytochrome c

Article Abstract:

The calculation of diffusion-limited rates of forming loops in polypeptide chains is done by a simple theory without the use of experimental parameters. Through the use of dimensional analysis, forming loops of various sizes are estimated. The results obtained from the application of the theory show that the time needed to form a tertiary contact between met80 and his 18 in Cytochrome c is 40 microns. An earlier misleading application of the theory is also corrected because of the obtained answers.

Protein folding, Polypeptides, Cytochrome c

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Influence of surface interactions on folding and forced unbinding of semiflexible chains

Article Abstract:

The folding and forced unbinding transitions of adsorbed semiflexible polymer chains using theory and simulation were investigated. At the elementary level, the processes describe a number of biological phenomena that included adhesive interactions between protein and tethering of receptors to cell walls.

Polymers, Plant cell walls, Cell walls

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