Effect of chelation to lanthanum ions on the photodynamic properties of hypocrellin A

Article Abstract:

Hypocrellin A (HA), an efficient phototherapeutic agent, can chelate with lanthanum ion to form a 1:1 complex, which exhibits enhanced (super 1)O2 generation yield, a red-shifted absorption window greatly improved water solubility, a much lengthened triplet excited state lifetime, and an increased affinity to DNA with respect to HA. The effects in turn lead to a more potent photodamage ability on calf thymus DNA for La(super 3+)-HA in both aerobic and anaerobic conditions, indicating the potential application of La(super 3+) HA in the field of photodynamic therapy.

All Other Basic Inorganic Chemical Manufacturing, Biological Product (except Diagnostic) Manufacturing, Drugs, All Other Miscellaneous Chemical Product and Preparation Manufacturing, Chelating Agents, Chemical preparations, not elsewhere classified, Industrial inorganic chemicals, not elsewhere classified, Deoxyribonucleic Acid, Lanthanum & Compounds, DNA, Excited state chemistry, Lanthanum

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Photodynamic properties of dipeptide-modified hypocrellin B derivatives: The role of tyrosine and tryptophan groups

Article Abstract:

Three long-wavelength absorbing dipeptide-modified hypocrellin B (HB) derivatives are prepared, their abilities to produce free radicals and singlet oxygen are compared with EPR technique and their binding interactions with calf thymus DNA (CT DNA) are studied. These derivatives possess moderate photodamage abilities on CT DNA even in anaerobic conditions.

Analysis, Cancer, Quinone, Quinones, Ultraviolet spectroscopy, Photochemotherapy, Structure

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ESR signal of superoxide radical anion adsorbed on TiO2 generated at room temperature

Article Abstract:

The porphyrin-capped TiO2 nanoclusters in neutral ethanol solution is used to investigate the interfacial electron transfer (ET) process. The study revealed that the ESR signal of superoxide radical anion under the irradiation of pulsed laser at 532 nm is generated at room temperature.

Electron transport, Superoxide, Superoxides, Electron paramagnetic resonance, Anions

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