Electrostatic effect on electron transfer at the active site of heme peroxidases: a comparative molecular orbital study on cytochrome C peroxidase and ascorbate peroxidase

Article Abstract:

Research was conducted to examine the hypothesis based on semiempirical molecular orbital calculations that the close surrounding and the protein bulk electrostatically stabilize different protonation states of the three H-bonded amino acids of the proximal side in cytochrome C peroxidase (CcP) and ascorbate peroxidase (Apx). An investigation of the hypothesis was performed based on discretized Poisson-Boltzmann measurements and ab initio minimal basis set molecular orbital. Results show that the active state behavior of CcP and Apx is explained by their different protonation motifs.

Binding sites (Biochemistry), Active sites (Biochemistry), Peroxidase, Cytochrome oxidase, Molecular orbitals

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OH radical induced one-electron oxidation of serotonin and tryptamine

Article Abstract:

An investigation of the one-electron oxidation of serotonin, tryptamine, 5-methoxytryptamine, N-methyltryptamine and N(1)-methyltryptophan assists in the elucidation of the reaction mechanisms of hydroxyl radicals with tryptamine and serotonin under a range of pH conditions.

Hydroxylation

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