Hexamerization of the bacteriophage T4 capsid protein gp23 and its W13V mutant studied by time-resolved tryptophan fluorescence

Article Abstract:

Time-resolved and steady-state fluorescence of the intrinsic protein fluorophore tryptophan is used to study the bacteriophage T4 capsid protein gp23. Denaturation of the N-terminus in hexameric wild type gp23 is observed around 40 degrees C, additionally the lifetimes obtained from time-resolved fluorescence measurements could tentatively be assigned to specific trytophan residues with the help of homology model of gp23.

Tryptophan, Viral proteins, Structure, Bacteriophage T4

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Near-infrared fluorescence imaging with water-soluble lead salt quantum dots

Article Abstract:

The water-soluble quantum dots of lead salts are analyzed for their applications in nanoscale fluorescence imaging of the cells. The carboxylic groups present on the external surface of the water-soluble quantum dots can actively participate in the target-specific labeling of cells.

Cancer cells, Spectra, Lead compounds, Salts

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Computational clues for a new mechanism in the glycosylase activity of the human DNA repair protein hOGG1. A generalized paradigm for purine-repairing systems?

Article Abstract:

The study results of the catalytic cycle responsible for the glycosylase activity of the human DNA repair protein hOGG1: enzyme activation, cleavage of the glycosidic bond, and expulsion of the damaged base is presented.

Analysis, DNA repair, Glycosylation, Purines

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