Kinetics of accumulation of molecules into liposomes

Article Abstract:

A model was presented for the calculation of the kinetics of loading agents or drugs into the liposomes and lipid vesicles. The importance of liposomes in drug delivery systems had been studied previously showing that the aggregation of external molecules into preformed liposomes was mediated by various gradients. The model had four compartments and used Fick's first law for the rate-determining transmembrane movement. The effect of the different parameters on the time course of loading liposomal systems was explained through the simulations undertaken by the model.

Drug delivery systems, Liposomes

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Molecular size-based model to describe simple organic liquids

Article Abstract:

Research was conducted to examine the possibilities of a simple, molecular size-based model that permits a unified description and estimation of solubilities, vapor pressures, partition coefficients, enthalpies of vaporization and boiling points for various simple organic liquids. The model uses a free energy expression derived from specific, molecular-level assumptions. Results indicate that the model gives a unified treatment for various processes in simple organic liquids where no strongly specific interactions are present.

Research, Organic solvents

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Molecular realism in default models for information theories of hydrophobic effects

Article Abstract:

Default models are derived to analyze physical arguments about contributions to hydrophobic hydration of inert gases. Tests were performed on physical features such as packing or steric effects and the role of attractive forces that decrease solvent pressure. It is shown that packing effects and packing effects plus active forces do not improve predictions of hydrophobic effects. However, these effects can be predicted by a cluster Poisson model incorporating tetrahedral coordination structure into the the default model.

Analysis, Hydration, Rehydration solutions, Noble gases, Gases, Rare

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