Length dependent helix-coil transition kinetics of nine alanine-based peptides

Article Abstract:

The helix-coil transition kinetics of a series of Ala-based alpha helical peptides of different lengths with and without end caps are examined by using time-resolved infrared spectroscopy coupled with laser-induced temperature jump initiation method. The findings reveal that efficient end-capping sequences can not only stabilize preexisting helices but also promote helix formation through initiation.

Usage, Infrared spectroscopy, Alanine

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Conformational distribution of a 14-residue peptide in solution: A Fluorescence resonance energy transfer study

Article Abstract:

A study is conducted which demonstrates that a nitrile-derivatized phenylalanine residue, p-cyanophenylalanine, and tryptophan constitute a novel donor-acceptor pair for fluorescence resonance energy transfer (FRET). The FRET efficiencies obtained from these peptides allowed us to gain a global picture regarding the conformational distribution of the MPx peptide in different environments.

All Other Basic Organic Chemical Manufacturing, Industrial Organic Chemicals, Nitriles, Phenylalanine, Chemical properties, Energy transformation

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Probing the kinetics of membrane-mediated helix folding

Article Abstract:

A new method for directly assessing the kinetics of helix formation accompanied by the peptide-membrane association is reported. The [Phe.sub.CN] and Trp fluorescence resonance energy transfer (FRET) pair, in conjunction with the stopped-flow technique could be used to directly monitor the coil-to-helix transition dynamics of membrane-binding peptides.

Analysis, Fluorescence, Protein folding

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