Exploring the motional dynamics of end-grafted DNA oligonucleotide by in situ electrochemical atomic force microscopy

Article Abstract:

The atomic-force electrochemical microscopy (AFM-SECM) is used to probe the conformation and motional dynamics of nanometer-sized single-stranded (ss) and double-stranded (ds) DNA oligonucleotides end-tethered to electrode surfaces. The dissimilar dynamical behavior of ss- and ds-DNA has shown that hybridization can be easily locally detected at the scale of 200 molecules by AFM-SECM.

Usage, Atomic force microscopy, Structure, DNA microarrays, Report

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Molecular dynamics study on the interaction of a mithramycin dimer with a decanucleotide duplex

Article Abstract:

The complex of a minor groove binding drug mithramycin (MTR) and the self-complementary d(TAGCTTAGCTA) 10-mer duplex was investigated. The findings indicated that the first (MTR)2Mg(super 2+) complex with the DNA duplex to form a 1:1 duplex complex do not cause stiffening of the duplex especially in the unoccupied site of the duplex.

Analysis, Molecular dynamics

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