What is the initial chemical precursor of DNA strand breaks generated by direct-type effects?

Article Abstract:

The study tests the hypothesis that the majority of DNA strand breaks produced by direct-type effects are due to sugar free radical precursors and that these radicals are produced by direct ionization of the sugar-phosphate backbone or by hole transfer to the sugar from tightly bound water. The approach entails determining the free radical dose response of well-defined crystalline DNA samples irradiated at 4 K.

Ionization, Free radical reactions

---

Diffusion approach to long distance charge migration in DNA: time-dependent and steady state analytical solutions for the product yields.

Article Abstract:

An analytical solution for unbiased charge transfer through regular DNA sequence via a hopping mechanism for time-dependent and steady state problems is listed. The biggest advantage of this approach is the capability of describing analytically time-resolved and steady state kinetics of charge migration in DNA.

Nucleotide sequence, Base sequence, Chemistry, Analytic, Analytical chemistry

---

Similar abstracts:

• Abstracts: Ab initio calculations of NMR parameters of highly coordinated oxygen sites in aluminosilicates. Proton transfer in hydrated microporous aluminosilicates: A (super 1)H NMR study of zeolite chabazite
• Abstracts: Phase transition behavior of fluorinated monolayers at the water-hexane interface. Phase studies by diffusive interfacial transport using near-infrared analysis for water (DIT-NIR)
• Abstracts: Theoretical studies of the hydrostatic compression of RDX, HMX, HNIW, and PETN crystals. Theoretical studies of solid nitromethane
• Abstracts: Comparative study of the folding free energy landscape of a three-stranded beta-sheet protein with explicit and implicit solvent models
• Abstracts: Effects of chromium substitution on the chemical bonding nature and electrochemical performance of layered lithium manganese oxide

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.