Catalytic versatility, stability, and evolution of the (beta)(alpha)(sub 8)-barrel enzyme fold

Article Abstract:

The topology of the (beta)(alpha)(sub 8)-barrel fold, its distribution in nature, and some of its most remarkable catalytic performances are reviewed. The findings show that the (beta)(alpha)(sub 8)-barrel enzyme fold is particularly suitable to understand the structural basis of enzyme catalysis, stability, folding and evolution because it occurs frequently, is catalytically versatile, and harbors active sites with high functional and structural plasticity.

North Carolina, Nuclear magnetic resonance spectroscopy, Crystallography

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Catalytic promiscuity and the divergent evolution of DNA repair enzymes

Article Abstract:

The DNA repair exhibits an evolvable system, allowing for flexibility in recruiting any enzyme to a new function, so that gene duplication in a redundant DNA repair activity would not be required. Most DNA repair enzymes have broad substrate specificity, enabling an abundant source of enzymes with low promiscuity to simplify DNA repair activity.

Gene mutations, Gene mutation, DNA repair

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Strategies in making cross-linked enzyme crystals

Article Abstract:

Chemical modification (super 102) of the enzymes is carried out to stabilize and modify their catalytic activity. By cross-linking the chemically modified enzyme, a new type of chemically engineered (super 103) enzyme is produced, and the cross-linked enzyme technology can be extended very well to genetically engineered enzymes.

Chemical engineering

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