Comparative QSAR: angiotensin II antagonists

Article Abstract:

Research has been conducted on the nonpeptide angiotensin antagonists. The role of the vasoactive hormone angiotensin II produced by the renin-angiotensin system has been reviewed and discussed.

Physiological aspects, Peptides, Hormones, Angiotensin, Angiotensins, Chemistry, Organic, Organic chemistry, Renin

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Chem-bioinformatics and QSAR: a review of QSAR lacking positive hydrophobic terms

Article Abstract:

This review examines the necessity of establishing a database for quantitative structure-activity relationships (QSAR) of chemical-biological interactions for applying bioinformatics to the biological systems. Data indicate that lack of hydrophobic terminology hinders interpretation of biological activities occurring at the cell surface and membrane systems from mechanistic organic chemistry point of view.

Physiological regulation, Biological control systems, Structure-activity relationships (Biochemistry), Membranes (Biology), Computational biology

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Comparative QSAR analysis of estrogen receptor ligands

Article Abstract:

The interaction of estrogens with the estrogen receptor is investigated. A quantitative structure activity relationship (QSAR) database was built which contained 12,500 examples of interactions between estrogen receptors and its ligands. The experiments used different receptor preparations and different ligands. The results showed that a common feature of the QSAR equations was the lack of a positive hydrophobic parameter. The interactions between the receptors and the substituents of the ligands can be quantitatively explained by electronic and steric parameters.

Ligands (Biochemistry), Estrogen, Estrogen receptors

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