Comparative QSAR analysis of 5-alpha-reductase inhibitors

Article Abstract:

A comparative quantitative structure-activity relationship investigation has been undertaken to establish a basis for the design of potent 5-alpha-reductase and adrenal 3-beta-hydroxy-delta5-steroid dehydrogenase/3-keto-delta5-steroid isomerase inhibitors. A number of generalizations are presented, including the fact that four or six azasteroids are appropriate molecules to inhibit all three types of enzymes.

Enzyme inhibitors

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Comparative QSAR study of tyrosine kinase inhibitors

Article Abstract:

Research has been conducted on the tyrosine kinase inhibitors. The use of QSAR in investigating the inhibitory activity of a number of compounds against these protein tyrosine kinases is described.

Statistical Data Included, Biochemistry, Tyrosine

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Cyclooxygenase (COX) inhibitors: a comparative QSAR study

Article Abstract:

The authors review the publications on cyclooxygenase (COX) inhibitors. The topics of interest include the analysis of QASAR studies of COX-1 and COX-2 inhibitors.

Analysis, Comparative analysis, Composition, Biosynthesis, Chemical research, Chemical inhibitors, Properties, Chemical properties, Cyclooxygenases

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