Properties and production of valienamine and its related analogues

Article Abstract:

The authors review the publications on valienamine and its related pseudo-sugars. The topics of interest include the absolute configurations of these compounds, the methods developed for the production of the compounds, and the application of valienamine and its related pseudo-sugars as inhibitors of processing enzyme glucosidase I in cancer treatment and as inhibitors of the HIV replication-etiologic agent for AIDS and AIDS-related complexes.

China, All Other Basic Organic Chemical Manufacturing, Industrial organic chemicals, not elsewhere classified, Enzymes, Other Basic Organic Chemical Manufacturing, Glucosides, Causes of, HIV (Viruses), HIV, Composition, Cancer, Chemical research, Amines, Chemical inhibitors

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Chemotherapeutic interventions targeting HIV interactions with host-associated carbohydrates

Article Abstract:

HIV-I entry mechanisms are reviewed with a particular emphasis on viral and host cell receptor structural features. The three-dimensional structure of this protein in addition to specific regions, where contacts are made with the host cell is also presented.

Science & research, Research, HIV infection, HIV infections, HIV antibodies

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Synthesis and conformational and biological aspects of carbasugars

Article Abstract:

The article reviews the progress made in the chemistry, synthesis and biology of carbasugars until May 2004.

Chemical synthesis, Ring formation (Chemistry), Cyclization (Chemistry)

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