Research at the interface between chemistry and virology: development of a molecular flashlight

Article Abstract:

The dramatic rise in HIV-infected persons has significantly contributed to the explosion of interest in the approaches to antiviral therapies. This review focuses on elucidating the antiviral activity of naturally occurring polycyclic quinone hypericin. The discussion includes the dependence on light of this antiviral drug for virucidal activity through targeted light delivery, also referred to as the 'molecular flashlight.' The synthesis of the components of molecular flashlight and the mechanism involved in its intermolecular proton transfer is also presented.

Research, Antiviral agents, Hypericin

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Chemistry of 7-azabicyclo(2.2.1)hepta-2,5-dienes, 7-azabicyclo(2.2.1)hept-2-enes, and 7-azobicyclo(2.2.1)heptanes

Article Abstract:

The (4 + 2) cycloaddition reaction between dienophiles and pyrroles generates 7-azabicyclo(2.2.1)hepta-2,5-dienes and 7-azabicyclo(2.2.1)heptanes. The 7-azabicyclo(2.2.1)hepta-2,5-dienes are an important precursor for various syntheses. New synthetic ways for the preparation of 7-azabicyclo(2.2.1)heptane derivatives and the chemical, physical, and biological properties of these compounds are discussed.

Analysis, Cyclic compounds, Ring formation (Chemistry), Cyclization (Chemistry)

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