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gem-Disubstituent effect: Theoretical basis and synthetic applications

Article Abstract:

The biological implications for the gem-disubstitution in the mechanism of enzymatic catalysis and the numerous applications in the design of new pharmaceutical are described. The conclusions state that the origin of the gem-disubstituent effect might vary depending on the system being analyzed.

Author: Jung, Michael E., Piizzi, Grazia
Publisher: American Chemical Society
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
All Other Miscellaneous Chemical Product and Preparation Manufacturing, Catalysts, Chemical preparations, not elsewhere classified

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Synthetic methods for azaheterocyclic phosphonates and their biological activity

Article Abstract:

Amino phosphonates and aminophosphonic acids are the topics of interest for a variety of socially relevant fields like medicinal, pharmaceuticals, agrochemical and biochemical. Various subdivision and classification of these compound based on the reaction which it undergoes is detailed.

Author: Moonen, Kristof, Laureyn, Inge, Stevens, Christian V.
Publisher: American Chemical Society
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2004
Phosphonates

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Human pharmaceuticals in the aquatic environment: A challenge to green chemistry

Article Abstract:

The background of pharmaceuticals in the environment problems and uncertainties are discussed. Focus is laid on pharmaceuticals used in human medicine, some of which are also applied in veterinary medicine.

Author: Collins, Terrence J., Khetan, Sushil K.
Publisher: American Chemical Society
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2007
United States, Health aspects, Environmental aspects, Pharmaceutical chemistry, Chlorination, Drug toxicity

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Subjects list: Drugs, Chemical properties, Research
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