Release of stored retinol from adipocytes

Article Abstract:

Adipose tissue is a storage site for retinol. However the major storage site is still the liver. Retinol is stored in adipose tissue in part as retinyl esters. Research with cultured mouse adipocytes demonstrated that retinyl esters are hydrolyzed by a hormone-sensitive lipase after exposure to cAMP, resulting in release of free retinol.

Physiological aspects, Adipose tissues, Adipose tissue, Vitamin A

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A case of human vitamin A deficiency caused by an inherited defect in retinol-binding protein without clinical symptoms except night blindness

Article Abstract:

The cause of night blindness and mild retinal dystrophy, two clinical symptoms of vitamin A deficiency suffered by two German siblings was found to be an inherited defect, two point mutations in the retinol-binding protein and very low plasma retinol as well as vitamin A deficiency.

Germany, Risk factors, Genetic aspects, Blindness, Vitamin A deficiency

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