Folic acid, 5-methyl-tetrahydrofolate and 5-formyl-tetrahydrofolate exhibit equivalent intestinal absorption, metabolism and in vivo kinetics in rats

Article Abstract:

The bioavailability of various folate derivatives was analyzed in rats. Radiolabeled folic acid, and two tetrahydrofolate compounds were introduced intragastrically to male rats and tissue, urine and fecal samples were taken for analyses. Results indicated complete intestinal absorption of all folate compounds, although transport follows saturation kinetics. Excretion is mainly via the kidney. Tissue handling was noted to be constant except in the brain which showed slower folate metabolism. These results suggested that the tissue kinetics is not indicative that overall folate bioavailability in different diets.

Folic acid, Metabolism, Folic acid in animal nutrition

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Dietary ascorbic acid depresses plasma and low density lipoprotein lipid peroxidation in genetically scorbutic rats

Article Abstract:

The influence of dietary ascorbic acid on plasma and lipoprotein lipid peroxidation was studied in genetically-altered rats incapable of in vivo synthesis of the compound. Results indicated that exogenous ascorbic acid supplementation influenced weight gain and decreased lipid peroxidation in a dose-dependent manner. A 300 milligram daily supplement was suggested to maintain normal levels of lipid peroxidase in plasma and liver low density lipoproteins. Its antioxidant activity may be of benefit in preventing endothelial damage and atherosclerosis.

Prevention, Atherosclerosis, Vitamin C, Lipid peroxidation, Vitamin C in animal nutrition

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Varied protein intake alters glutathione metabolism in rats

Article Abstract:

The relationship between dietary protein content and glutathione (GSH) metabolism in rats was evaluated. Rats fed high protein diets did not have increased liver GSH content, plasma GSH turnover, or plasma methionine and cysteine contents as compared to controls acclimated to 20% casein-based purified diets. A sigmoidal relationship between total GSH flux and liver GSH content was shown. Noninvasive blood sampling of the various parameters showed that the best indirect predictor of liver GSH content was plasma cysteine levels.

Health aspects, Dietary protein, Glutathione metabolism, Proteins in animal nutrition

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