Incorporation of 3H-label from folic acid is tissue-dependent in folate-deficient rats

Article Abstract:

Patterns of folate depletion and incorporation in folate-deficient and control rats were monitored in various tissue types. The results showed that during folate deficiency, the decrease in endogenous folate levels depends on the tissue type, with brain tissue being most resistant to folate depletion. The rates of folate incorporation determined by tracing the fate of 3H-labeled folate showed that resistance to folate depletion is due to greater rates of incorporation of exogenous folate.

Folic acid, Liver, Brain

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Mitotic activity in mice is suppressed by energy restriction-induced torpor

Article Abstract:

A study was done on the effect of energy restriction-induced torpor on mitotic activity in mice by monitoring body core temperature using telemetry. Results show inhibition in the development of cancer as well as extended longevity in the mouse strains subjected to the energy restriction regimen. Energy restriction was found to decrease mitotic activity and it was further shown that torpor plays an important function in suppressing mitosis.

Mitosis, Tumors

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Folate deficiency alone does not produce neural tube defects in mice

Article Abstract:

The role of folic acid deficiency in neurolation was investigated. Mice were fed an amino acid-based diet containing various levels of folic acid, and the incidence of neural tube defects were monitored from embryos to dams. The results showed that folic acid deficiency inhibits normal reproduction in mice. However, folic acid deficiency, per se, is not sufficient to produce neural tube defects.

Abnormalities, Neural tube, Neural tube defects

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