Increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio increases tumor necrosis factor production by murine resident peritoneal macrophages without an effect on elicited peritoneal macrophages

Article Abstract:

Stimulation of tumor necrosis factor (TNF) by varying ratios and levels of dietary (n-3) and (n-6) fatty acids was studied. Increased dietary (n-3):(n-6) fatty acid ratio from zero to one increased the production of cell-associated and secreted TNF by residential peritoneal macrophages. However, increasing the total concentration of dietary (n-3) fatty acids does not affect the production of TNF. Moreover, production of elicited macrophages was not affected by the fatty acid stimulation. These may explain the effects of various dietary oils on the production of TNF which is beneficial in inflammatory and immune-related disorders only at low levels.

Research, Food and nutrition, Mice, Mice (Rodents), Macrophages, Tumor necrosis factor, Unsaturated fatty acids

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Protein deficiency impairs erythropoiesis in rats by reducing serum erythropoietin concentration and the population size of erythroid precursor cells

Article Abstract:

A study was done on the effect of protein deficiency on erythropoiesis using enzyme-linked immunosorbent assay of rat erythropoietin. Results show a decrease in serum erythropoietin concentration caused by protein deficiency thereby resulting to impaired erythropoiesis. There is also an observed reduction in the population size of erythropoietin target cells in the spleen which is the primary site of erythropoiesis in rats.

Physiological aspects, Erythropoietin, Erythropoiesis, Protein deficiency

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