Special considerations in the design of trials involving children

Article Abstract:

Important considerations must be taken into account before involving children as subjects for clinical trials or research. Aside from ethical concerns, children, unlike adults, are not qualified to decide for themselves. In addition, using children as research subjects provides clinical researchers with tools that are not present in adults because they are expected to grow and develop physically. The importance of determining growth and physical development in evaluating the effects of experimental therapies and the measurement of peptide components of the insulin-like growth factors system in determining experimental therapies for catabolic states are discussed.

Evaluation, Measurement, Physiological aspects, Children, Clinical trials, Ethical aspects, Peptides, Insulin-like growth factors, Somatomedins, Therapeutics, Experimental, Therapeutics research

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Sucrose permeability as a marker for nonsteroidal anti-inflammatory gastroduodenal injury: how sweet is it?

Article Abstract:

Assessment of patients undergoing endoscopy and volunteer consumers of anti-inflammatory drugs revealed the benefits of sucrose in evaluating proximal gastrointestinal injury in its capacity as permeability markers. The sucrose permeability test is of use in identifying patients likely to suffer side effects of consuming nonsteroidal anti-inflammatory drugs.

Diagnosis, Gastrointestinal diseases, Sucrose

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Similar abstracts:

• Abstracts: Summary remarks. Working group session report: special considerations in trials involving children
• Abstracts: Viewpoint on National Institutes of Health clinical guidelines

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