Replication of the human immunodeficiency virus 1 and impaired differentiation of T cells after in vitro infection of bone marrow immature T cells

Article Abstract:

When normal human bone marrow cells are infected with the HIV virus (the virus which is associated with AIDS) a depletion of mature T cells was found (T Cells are a type of white blood cell, the lymphocyte, which are embryologically derived from the thymus gland. These cells are involved in the immune process.). The authors used laboratory techniques to study the rate of development of specific bone marrow derived cells. Results indicate that cells infected with HIV were depleted of T cells and were impaired in their ability to develop into more mature cell forms. The authors suggest that the HIV-1 virus can infect immature bone marrow T cells and that this infection can be transmitted to subsequent generations of cells. They also demonstrate that massive replication of the virus only occurred in those cells that were more matured.

HIV (Viruses), HIV, Disease transmission, T cells, Retrovirus infections

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Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis

Article Abstract:

Inflammation of the joints causes individuals to experience pain with movement, as well as tenderness, redness and swelling (e.g., arthritis). This study examined the ability of cells in the linings of joints (synoviocytes) to produce and release interleukin (growth promoting substance) into the fluid within the joint space (synovial fluid). The synovial fluid from patients with various types of joint inflammations was demonstrated to contain higher levels of interleukin-6; however, patients with osteoarthritis showed lower levels. These results suggest that interleukin-6 may be important to the general manifestation of inflammatory diseases of the joints.

Causes of, Physiological aspects, Rheumatoid arthritis, Interleukins, Synovial membranes, Synovial membrane

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Osteoclast-like cells form in long-term human bone marrow but not in peripheral blood cultures

Article Abstract:

Studies of transplanted tissues have suggested that small cells found in circulating blood may be precursors of a normal bone cell, the osteocyte, that helps to maintain bone tissues. This hypothesis was tested in the laboratory over an extended period of time. From the bone marrow of cats, baboons and humans a similar cell demonstrates many characteristics of osteoclasts, a normal cell found in bone active in the absorption and removal of unwanted tissue. However, the small cells found circulating in the blood appear to be capable of becoming osteoclasts.

Bone marrow, Blood cells

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