Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1. Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163-171

Article Abstract:

Hyaluronic acid is believed to play a critical role in wound healing and in the development of an embryo. (Hyaluronic acid is found in the fluid of joints, the gel of the eye and is a component of cartilage, umbilical cords, connective tissue of skin, and blood vessels.) Factors which control the production of hyaluronic acids are largely unknown. Various interleukins, growth promoting substances, were used in the study. Some were produced by genetic technologies (recombinant methods). Natural and recombinant interleukin were able to cause the production of hyaluronic acid in the laboratory. The production and secretion of interleukin could potentially signal the production of hyaluronic acid which could in turn after cell-to-cell communication and induce changes in binding sites on cells that act as triggers for other events.

Physiological aspects, Wound healing, Biomedical materials, Biomaterials, Body fluids

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Response of simian virus 40 (SV40)-transformed, cultured human marrow stromal cells to hematopoietic growth factors

Article Abstract:

Human bone marrow cells were grown in the laboratory after being injected with a monkey virus which is known to make cells transform (become cancerous). The transformed bone marrow cells were treated with various growth factors, including genetically produced growth factors (recombinant factors) such as interleukin one. Cells treated with growth factors formed few organized structures. However the growth of cells treated with recombinant factors was much more developed. Cells not stimulated by various growth factors did not show such increased growth activity while those which were stimulated did.

Causes of, Carcinogenesis, Colony-stimulating factors (Physiology), Colony-stimulating factors, Simian viruses

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Interleukin 1 and tumor necrosis factor stimulate human vascular endothelial cells to promote transendothelial neutrophil passage

Article Abstract:

The ability of neutrophils (white blood cells containing granules) to pass through small vessel walls and enter tissues is explored by using several factors known to increase the migrating ability of the neutrophils. The effects of these factors on veins removed from human umbilical cords was found to be proportional to the amount of the factor used and the period of time it was used. This finding was confirmed with the electron microscope. In direction of the migration of the neutrophils across the vessel walls was also influenced by the use of interleukin (a growth promoting substance).

Neutrophils

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