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A 58-year-old man with common variable immunodeficiency, splenomegaly, and hemolytic anemia

Article Abstract:

A 58-year-old man with a history of common variable immunodeficiency was diagnosed with B-cell lymphoma. He had a history of recurrent sinus infections and was found to have a deficiency in immunoglobulin (antibody) production. He was treated with high-dose corticosteroids, immune globulin and antibiotics for his sinus infections. Eight years after this diagnosis, he was admitted to a hospital with fever, anemia, chest pain and an enlarged spleen. A CT scan also revealed enlarged lymph nodes around his kidneys. His spleen was removed and the lymph nodes were biopsied. Microscopic analysis revealed a B-cell lymphoma and infection by the Epstein-Barr virus and cytomegalovirus.

Author: Girardet, Christophe, Wong, Johnson T.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1995
Immunodeficiency

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A hidden agenda

Article Abstract:

A 35-year-old man entered the hospital for fever, nausea, vomiting, and abdominal pain. Initial test results did not suggest bacterial infection, and extensive tests for liver, gallbladder, viral, and other conditions were undertaken. The patient had antibodies to the hepatitis B core antigen. Doctors suspected he was infected with HIV, but the patient refused testing. Immunoblastic lymphoma was ultimately diagnosed, and the patient admitted hiding his HIV-positive status. Extensive unnecessary testing had been undertaken because the patient concealed his HIV infection.

Author: Landor, Michael
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
Diagnosis, Complications and side effects, Medical examination, HIV infection, HIV infections, HIV patients, Fever

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A 57-year-old woman with fever, sweats, neuropathy, and multiple pulmonary nodules

Article Abstract:

A 57-year-old woman was admitted to a hospital with fever, sweating, weakness and a history of masses in her lungs. A CT scan revealed a series of masses in her lungs. She also had a rash on her buttock which was diagnosed as herpes zoster. Lung function tests showed a mild obstructive defect. Needle-aspiration biopsy of her lungs revealed evidence of a lymphoma. This was confirmed by an open biopsy of her lung. She did not respond to chemotherapy and a bone marrow biopsy showed that the disease had spread to the bone marrow.

Author: Donat, Walter E., Savilo, Elena
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996

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Subjects list: Case studies, Lymphomas
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