A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep-vein thrombosis

Article Abstract:

Placing a filter in the vena cava to prevent blood clots from spreading from the legs to the lungs may have serious complications. The vena cava is the large vein that returns blood to the heart. In 400 patients who had blood clots in the large veins of the leg, 200 were given a filter in the vena cava and 200 were not. Initially, those with a filter had fewer blood clots in the lungs, but within two years, they were more likely to have recurring blood clots in the legs. This may occur because blood clots form around the filter. Low-molecular-weight heparin was as effective as unfractionated heparin in preventing blood clots in these patients.

Care and treatment, Evaluation, Prevention, Pulmonary embolism, Filters (Separation), Thrombosis, Deep vein, Deep vein thrombosis

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Appetite-suppressant drugs and the risk of primary pulmonary hypertension

Article Abstract:

Long-term use of diet pills containing fenfluramine or its derivatives may increase the risk of pulmonary hypertension. This lung disease is characterized by high blood pressure in the blood vessels of the lungs. Researchers compared the use of fenfluramine and its derivatives by 95 people with pulmonary hypertension and 355 healthy volunteers. Use of fenfluramine and its derivatives led to a six-fold increased risk of pulmonary hypertension. Those who took the drugs for more than three months had 23 times the risk.

Health aspects, Weight reducing preparations, Anti-obesity agents

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Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine: a systematic review of the evidence

Article Abstract:

Animal studies show that fenfluramine and its derivative dexfenfluramine both cause damage to nerve cells in the brain that produce serotonin. It is not known whether this occurs in humans. These appetite suppressants go by the trade names Pondimin and Redux, respectively. A review of the animal studies found that the doses that cause damage in animals are the same doses used in humans to treat obesity. These drugs also increase the risk of pulmonary hypertension, especially when used for more than 3 months.

Neurons

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