A comparison of differing dosing regimens of vaginally administered misoprostol for preinduction cervical ripening and labor induction
Article Abstract:
More frequent vaginal doses of misoprostol to ripen the cervix before induction of labor may offer advantages over spacing doses wider apart. Researchers randomly assigned 522 women requiring labor induction to a maximum of 8 doses given every 3 hours or 6 doses given every 4 hours. Average time to vaginal birth was shorter in the 3-hour regimen, and 42% of women required oxytocin stimulation of labor versus 51%. However, the cesarean rate was 21% overall and did not differ between groups, and more than one-third of fetuses in both groups experienced abnormal fetal heart rate patterns.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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A comparison of orally administered misoprostol with vaginally administered misoprostol for cervical ripening and labor induction
Article Abstract:
Vaginal misoprostol appears to be more effective than oral misoprostol for inducing labor. Misoprostol is prostaglandin that causes the cervix to ripen, which means the cervix is dilated and ready for delivery. Researchers randomly assigned 220 pregnant women who needed labor induction to take oral misoprostol or receive a vaginal suppository containing misoprostol. The women who received the suppository were more likely to deliver within 24 hours, had shorter labor, and required lower doses of misoprostol and oxytocin.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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- Abstracts: A comparison of intermittent vaginal administration of misoprostol with continuous dinoprostone for cervical ripening and labor induction
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