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Rationale for treatment of patients with chronic heart failure with adrenergic blockade

Article Abstract:

The use of beta blockers in the treatment of chronic heart failure is still under investigation. Beta blockers inhibit the activation of the sympathetic nervous system that usually occurs in chronic heart failure. The sympathetic nervous system is activated by damage to the heart that often occurs during a heart attack. The nerves release chemicals called catecholamines, which boost heart contractions to provide blood to organs. But the overproduction of catecholamines can also damage the heart. Beta blockers were first used in patients with heart failure in 1975, but it wasn't until 1985 that long-term studies were published. Some of the studies were too small to show a significant effect. The National Institutes of Health has funded a large study to determine the effectiveness of a beta blocker in 2,800 patients with heart failure.

Author: Mancini, Donna M., Sackner-Bernstein, Jonathan
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1995
Evaluation, Drug therapy, Heart failure, Adrenergic beta blockers, Adrenergic beta-antagonists

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Multistate outbreaks of Salmonella infections associated with raw tomatoes eaten in restaurants - United States, 2005-2006

Article Abstract:

The investigation into the multistate outbreak of Salmonella infections due to the consumption of raw tomatoes in restaurants across the United States is discussed.

Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2007
United States, Vegetables and melons, Other Vegetable (except Potato) and Melon Farming, Tomatoes, Health aspects, Development and progression, Salmonellosis, Raw foods

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