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A randomized trial of amnioreduction versus septostomy in the treatment of twin-twin transfusion syndrome

Article Abstract:

Left untreated, severe twin-to-twin transfusion syndrome (TTTS) presenting in the early second trimester of pregnancy is often associated with significant maternal morbidity and almost universal perinatal loss and the mainstay of therapy is found to involve removal of recessive amounts of amniotic fluid through serial amnioscenteses (amnioreduction). Comparison between the amnioreduction and intentional perforation of the intervening twin membrane is presented.

Author: Saade, George R., Fisk, Nicholas M., Dickinson, Jan E., Hassan, Sonia S., Sciscione, Anthony, Belfort, Michael A., Gagnon, Alain, Chitkara, Usha, Moise, Kenneth J., Jr., Johnson, Anthony, Wilson, R.D., Lamvu, Georgine, Dorman, Karen, O'Shaughnessy, Richard O., Skupski, Daniel
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2005
Science & research, Research, Usage, Fetal distress, Amniocentesis, Amniotic fluid

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Anti-D in Rh positive pregnancies

Article Abstract:

The clinical outcomes of anti-D isoimmunization are reviewed in a series of women who are typed Rh positive or Rh weak positive. In Rh positive or Rh weak positive pregnancies with anti-D isoimmunization, clinical hemolytic disease of the fetus and newborn (HDFN) is mild, however, such patients should be monitored for potentially significant HDFN, since the occurrence of HDFN, including neonatal death, is possible.

Author: Rossi, Karen Q., O'Shaughnessy, Richard W., Prasad, Mona R., Krugh, Dave
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2006
Health aspects, Risk factors, Pregnant women, Rh factor, Blood diseases, Hematologic diseases

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Amnioreduction versus septostomy in twin-twin transfusion syndrome

Article Abstract:

Septostomy appears to be more effective than amnioreduction in treating twin-twin transfusion syndrome. This syndrome causes one twin to grow at the expense of the other. Both twins are usually born prematurely, with mortality rates between 60% and 100%.

Author: Johnson, Jeffrey R., Rossi, Karen Q., O'Shaughnessy, Richard W.
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2001

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Subjects list: Care and treatment, United States, Fetofetal transfusion
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