A pathologic study of childhood lymphoma in Taiwan with special reference to peripheral T-cell lymphoma and the association with Epstein-Barr viral infection

Article Abstract:

Lymphomas are actually a diverse group of malignancies involving lymphatic cells. In the Untied States, lymphomas are the third most common childhood malignancy, but they exhibit great geographical diversity. In Africa, for example, lymphoma is the most common childhood malignancy. At least some of the geographical diversity of lymphomas appears to be due to variations in viruses which either cause or contribute to their development. Although the characteristics of adult lymphomas occurring in Taiwan have been tabulated, the occurrence of lymphomas among children in that country has escaped study. Over a 10-year period, 72 cases of malignant lymphoma occurring in children under 15 were identified at the National Taiwan Hospital; seven cases were excluded from further study. Of these cases, 86 percent were non-Hodgkin's lymphomas and the remaining 14 percent were Hodgkin's disease. This proportion of non-Hodgkin's lymphomas is greater than that of western nations but less than that of Africa. Most of the non-Hodgkin's lymphomas were aggressive tumors and the median survival time was eight months. The distribution of types of non-Hodgkin's lymphomas was found to be similar to the distribution of lymphomas among children in Japan and in western nations. Twenty-three of the cases were subjected to detailed genetic analysis for indications of Epstein-barr virus (EBV) and human T-cell lymphotropic virus type I (HTLV-I). No specimen was found to contain HTLV-I genes. However, four of six cases of peripheral T-cell lymphoma tested contained DNA from Epstein-Barr virus. Other forms of lymphoma did not contain evidence of EBV genes, which suggests that Epstein-Barr virus may be associated with this more aggressive type of lymphoma. (Consumer Summary produced by Reliance Medical Information, Inc.)

Taiwan, Physiological aspects, Lymphomas, Epstein-Barr virus

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The Risk of Venous Thromboembolic Disease Associated with Adjuvant Hormone Therapy for Breast Carcinoma: A Systematic Review

Article Abstract:

Venous thromboembolic events are complications of adjuvant hormone therapy for breast carcinoma. There is no reason to believe that the newer forms are any safer than tamoxifen.

HEALTH SERVICES, Cancer Therapy, Ambulatory Health Care Services, Complications and side effects, Risk factors, Breast cancer, Thrombophlebitis, Cancer treatment

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