Adjuvant whole-abdominal radiation therapy in uterine papillary serous carcinoma

Article Abstract:

Psammoma bodies are tiny layered concretions found in some pathological conditions. They were first described in cancer of the uterine endometrium (lining of the uterus) in 1961. Since that time, this special form of endometrial cancer has become recognized as a distinct disease, now called uterine papillary serious carcinoma (UPSC). The distinction is significant, since UPSC shows a great propensity for spread to the upper abdomen. Patients with UPSC generally have a poor prognosis. The treatment of the disease is primarily surgical, but the propensity for disease spread indicates that adjuvant treatment is necessary. The previous experience of the authors has indicated that adjuvant chemotherapy is not particularly effective in cases of UPSC. They now report their experience using adjuvant radiotherapy, given in the form of whole-abdominal radiation therapy (WART). Nine UPSC patients underwent WART after their recovery from surgery. The total dose of radiation given averaged 4,500 cGy. (A Gy, or Gray, is a dose of radiation equivalent to one joule of energy absorbed per kilogram of tissue. It is equal to 100 rads.) Three of the nine patients also received an additional boost of radiation to the vaginal apex. After an average follow-up time of just over two years, six of the nine patients relapsed, and four of these relapsed patients have died. It is worth noting that two of the three patients who remain disease-free received additional radiation to the vaginal apex. Furthermore, in three of the six patients who relapsed, recurrent cancer was found in the vaginal apex. These results suggest that although WART is apparently of little value for routine use, irradiation of the vaginal apex may prove useful. (Consumer Summary produced by Reliance Medical Information, Inc.)

Evaluation, Cancer, Radiotherapy, Uterine cancer, Adjuvant chemotherapy

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Colony-stimulating factor-1 in primary ascites of ovarian cancer is a significant predictor of survival

Article Abstract:

The level of colony-stimulating factor-1 (CSF-1) in ascites may predict survival in patients with ovarian cancer. Ascites is an accumulation of fluid in the abdominal cavity. Levels of CSF-1 were measured in samples of ascitic fluid from 37 women undergoing surgery for advanced ovarian cancer. Patients with low levels of CSF-1 survived significantly longer than those with high levels of CSF-1. The amount of residual disease after surgery was also a reliable predictor of survival. CSF-1 is a growth factor produced by certain types of cancer cells. The production of increased levels of CSF-1 may help cancer cells invade different types of tissues. Ovarian cancer patients with increased ascitic levels of CSF-1 may require more aggressive types of treatment.

Analysis, Physiological aspects, Development and progression, Ovarian cancer, Ascites, Colony-stimulating factors (Physiology), Colony-stimulating factors

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An unexpected effect of glucocorticoids on stimulation of c-fms prot-oncogen expression in choriocarcinoma cells that express little glococorticoid receptor

Article Abstract:

A study is conducted to determining the mechanism by which glucocorticoids stimulate c-fms proto-oncogene expression in JAR choriocarcinoma cells. One clone among several JAR clones were tested, that revealed that there was concordance between presence or absence of glcocorticoid receptor messenger RNA and glucocorticoid sensitivity.

United States, Science & research, Research, Influence, Corticosteroids, Messenger RNA, Choriocarcinoma, Glucocorticoids

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