Affinity labeling identifies histidine at the active site of human placental 3beta-hydroxysteroid dehydrogenase and steroid 5 (right arrow) 4-ene-isomerase

Article Abstract:

Only one binding site may exist on the multifunction enzyme 3beta-hydroxysteroid dehydrogenase and steroid 5 to 4-ene-isomerase. 3beta-hydroxysteroid dehydrogenase and isomerase catalyzes both dehydrogenase and isomerase reactions in the human placenta. A study examined the number of binding sites on 3beta-hydroxysteroid dehydrogenase and isomerase. The same binding site appeared to be involved in both dehydrogenase and isomerase activity. The products of the dehydrogenase reaction may cause a change in the shape of the enzyme around the binding site. 3beta-hydroxysteroid dehydrogenase and isomerase catalyzes reactions involved in the synthesis of both progesterone and estrogen.

Dehydrogenases, Oxidoreductases, Histidine, Isomerases

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Placental transfer of sulindac, sulindac sulfide, and indomethacin in a human placental perfusion model

Article Abstract:

The drug sulindac crosses the placenta just as easily as indomethacin. Both of these drugs are used to prevent premature labor but sulindac has fewer adverse effects on the fetus. Researchers analyzed the rate of transfer of sulindac, its major metabolite sulindac sulfide, and indomethacin in human placentas taken from women shortly after they gave birth. The placentas were exposed to all three drugs and the rate at which they moved from the maternal side to the fetal side was measured. All three crossed the placenta to some degree. Further research is needed to determine why sulindac has fewer side effects.

Research, Drug metabolism, Indomethacin, Sulindac

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Human placental growth hormone

Article Abstract:

Human placental growth hormone is secreted by the placenta during pregnancy and may have physiological effects on the mother and on the development of the placenta. The hormone begins to replace pituitary growth hormone in maternal circulation at 15 to 20 weeks gestation and predominates when the pregnancy reaches full term. Placental growth hormone secretion varies with maternal blood glucose levels, and may alter maternal metabolism and protect nutrient availability to the fetus. Placental growth hormone secretion is decreased in pregnancies with fetal growth restriction.

Fetus, Somatotropin, Fetal growth retardation

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