The cancer experience in the Framingham Heart Study cohort

Article Abstract:

The Framingham Heart Study was begun four decades ago for the purposes of following a large group of subjects over a long enough period of time to observe what factors influence the eventual development of heart disease. The 5,209 men and women who began the study were between 30 and 62 years old; the youngest subject today is therefore at least 70. It is to be expected, of course, that over four decades some of these subjects will develop cancer, and thus the same group of patients that has provided such useful information about heart disease may provide some insights into cancer as well. Using the medical records from the Framingham Heart Study, the authors have tabulated the occurrence of cancers in this well defined group. A total of 1,201 cancers could be confirmed, and the 14 most common cancers accounted for over 90 percent of the observed cases. (For purposes of comparison, 2,347 people in the same group have developed heart disease or stroke.) Among men, cancer of the lungs, prostate, skin, and colon accounted for over half the cases, while among women breast cancer, colon cancer, and skin cancer accounted for half. The median age at diagnosis was 69 years of age for men and 65 for women. Twenty percent of the women and 22 percent of the men have experienced cancer at some time. The data obtained from the Framingham Study were compared with data from the Connecticut Tumor Registry, which unlike the Framingham Study does not involve a predefined study population. Nevertheless, the incidence of various cancers in the Framingham Study was comparable to that calculated from data in the Connecticut Tumor Registry. Since a great deal more is known about the patients in the Framingham Heart Study than can be inferred from many tumor registries, the authors suggest that this data may provide an important resource for investigating cancer risk factors. (Consumer Summary produced by Reliance Medical Information, Inc.)

Statistics, Demographic aspects, Cancer, Framingham Heart Study

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Alcohol consumption and risk of breast cancer: the Framingham Study revisited

Article Abstract:

Alcohol consumption and risk of breast cancer are discussed based on study of data from the Framingham Study. Average alcohol consumption and different beverages were considered based on study of 2,764 women over 40+ years and 2,284 followed for as many as 24 years. Breast cancer was not seen to be associated with consumption of wine, beer or spirits assessed separately. Findings indicate that light consumption of alcohol or any type of alcoholic beverage is not associated with greater breast cancer risk. Many studies report increases in breast cancer risk with moderate to heavy alcohol consumption.

Statistical Data Included, Research, Epidemiological research, Cross sectional studies

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Alcohol consumption and risk of breast cancer: the Framingham Study revisited

Article Abstract:

It appears, based on data from the Framingham Study in Massachusetts, that light consumption of any kind of alcoholic beverage or alcohol is not associated with increased risk of breast cancer. No particular type of alcoholic beverage causes risk of breast cancer to rise. The study followed 2,764 women for 40 years+ and 2,284 women of the offspring cohort for 24 years. A potential exists for a residual confounding effect.

Usage, Cohort analysis

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