An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice

Article Abstract:

The mouse model for age-related macular degeneration incorporates deficiency in monocyte chemoattractant protein-1 or C-C chemokine receptor-2. The mice exhibit accumulation of lipofuscin and drusen in the retinal pigment epithelium, photoreceptor atrophy and choroidal neovascularization. Data suggest macrophage dysfunction as the cause of age-related macular degeneration pathogenesis.

Models, Causes of, Macrophages, Photoreceptors, Macular degeneration, Degeneration (Pathology), Optic atrophy

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Metformin reverses fatty liver disease in obese, leptin-deficient mice

Article Abstract:

Research addresses the relationship between fatty liver and insulin-resistance and hyperinsulinemia and evaluates the beneficial effects of insulin-sensitizing agent metformin. Results show that metformin reverses hepatomegaly and hepatic steatosis leading to an improvement in the liver disease. Mechanism of action of metformin is presented.

Statistical Data Included, Drug therapy, Genetic aspects, Obesity, Fatty liver, Leptin, Metformin, Genetics, Insulin, Insulin receptors

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Engineering functional two-and three-dimensional liver systems in vivo using hepatic tissue sheets

Article Abstract:

A new feasible option for liver tissue engineering to meet the substantial demand in several liver diseases is explored.

Care and treatment, Methods, Liver diseases, Tissue engineering

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