Angiogenesis in life, disease and medicine

Article Abstract:

The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair an imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Angiogenesis inhibitors are likely to change the face of medicine in next decade with more than 500 million people worldwide predicted to benefit from pro or anti-angiogenesis treatments.

Health aspects, Risk factors, Immunologic diseases

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Angiogenesis in health and disease

Article Abstract:

Angiogenesis was initially only implicate in cancer, arthritis and psoriasis but now it has become increasingly evident that excessive, insufficient or abnormal angiogenesis contributes to the pathogenesis of many more disorders. Molecular insights are generated into these processes that offer new therapeutic opportunities that are currently being evaluated.

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Regulation of angiogenesis by tissue factor cytoplasmic domain signaling

Article Abstract:

The tissue factor (TF)-VIIa protease complex, which is independent of triggering coagulation, promotes tumor and developmental angiogenesis through protease- activated receptor-2 (PAR-2) signaling. The efficacy of angiostatic treatments for cancer and neovascular eye diseases is enhanced through targeting the TF-VIIa signaling pathway.

Protease inhibitors

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