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Antibacterial treatment of gastric ulcers associated with Helicobacter pylori

Article Abstract:

A one-week course of antibacterial therapy may heal stomach ulcers associated with Helicobacter (H.) pylori infection. A study of 100 patients with stomach ulcers and H. pylori infection compared the antibacterial treatment to that of an acid-suppressing drug, omeprazole. One week of antibacterial therapy with bismuth subcitrate, tetracycline, and metronidazole resulted in healing of most of the ulcers, with a low rate of recurrence by one year. Treatment with omeprazole alone produced a lower rate of healing, but when combined with the antibacterial therapy, resulted in a much faster rate of healing. The findings point to H. pylori as the causal agent in stomach and intestinal ulcers. The presence of H. pylori at one year correlated strongly with the recurrence of ulcers.

Author: Sung, Joseph J.Y., Ng, Enders K.W., Chung, S.C. Sydney, Leung, Vincent K.S., Li, Arthur K.C., Yung, Man Yee, Ling, Thomas K.W., Li, Michael K.K., Cheng, Augustine F.B.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1995
Health aspects, Drug therapy, Antibacterial agents, Helicobacter infections, Peptic ulcer

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Identification of severe acute respiratory syndrome in Canada

Article Abstract:

Doctors describe the symptoms and outcome of 10 Canadians who developed severe acute respiratory syndrome, or SARS. Symptoms included a dry cough, fever, fatigue, and difficulty breathing. Five patients had to be placed on a ventilator and three died. A human metapneumovirus and a coronavirus were isolated from tissue samples from some of the patients.

Author: Petric, Martin, Slutsky, Arthur S., Rose, David, Low, Donald E., Brunham, Robert C., McGeer, Allison J., Poutanen, Susan M., Henry, Bonnie, Finkelstein, Sandy, Green, Karen, Tellier, Raymond, Draker, Ryan, Adachi, Dena, Ayers, Melissa, Chan, Adrienne K., Skowronski, Danuta M., Salit, Irving, Simor, Andrew E., Doyle, Patrick W., Krajden, Mel
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
Canada

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A major outbreak of severe acute respiratory syndrome in Hong Kong

Article Abstract:

Doctors report the symptoms and outcome of 138 patients in Hong Kong who were believed to have severe acute respiratory syndrome, or SARS. SARS is a lung disease that can be fatal in some patients. These patients were all admitted to a hospital between March 11 and March 25, 2003.

Author: Sung, Joseph J.Y., To, K.F., Lee, Nelson, Hui, David, Wu, Alan, Chan, Paul, Cameron, Peter, Joynt, Gavin M., Ahuja, Anil, Yung, Man Yee, Leung, C.B., Lui, S.F., Szeto, C.C., Chung, Sydney
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
Hong Kong

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Subjects list: Patient outcomes, Mortality, Physiological aspects, Prognosis, Severe acute respiratory syndrome
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