Antibiotics au naturel
Article Abstract:
Natural products research was a mainstay of the pharmaceutical industry for decades and was the main to the golden age of antibiotics discovery from 1940s to the 1960s when the vast majority of new antibiotic classes were introduced. Even in modern times, new naturally occurring antibiotics are still being discovered, though not necessarily developed from natural product libraries that are decades old like a new glycopeptides class, the mannopeptimycins, produced by a strain of Streptomyces hygroscopius, a series of antimicrobial peptides derived from the hemolymph of the Australian bull ant, and antimicrobial activity in four genera of Australian native bees.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Molecular engineering approaches to peptide, polyketide and other antibiotics
Article Abstract:
The advancement in technology and applications of molecular engineering or combinatorial biosynthesis to produce new antibiotics are presented. The examples demonstrate that molecular engineering could work to modify the properties of pharmacologically active secondary metabolites including antibiotics and could also be coupled with medicinal chemistry to carry out in depth structure-activity relationship (SAR) studies directed to optimizing the properties of important molecules.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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Modifying quinolone antibotics yields new anxiolytics
Article Abstract:
Patients taking fluroquinolone antibiotics such as norfloxacin exhibit a low incidence of convulsions and anxiety. Compound 4 is anxiolytic but does not cause sedation, it represents a new class of ligands that have anxiolytic activity without sedative liability.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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