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Sickle cell anemia in adults: avoiding crises, organ damage

Article Abstract:

Now that half of all patients with sickle cell anemia are surviving well into their 40's, many internists need to be aware of the treatments for preventing the severe complications of this disease. The most common complications are the acute chest syndrome and painful crises. These are both probably caused by the accumulation of sickled red blood cells in arteries, which cuts off the blood supply to the region supplied by the artery. This can ultimately damage the lungs, liver and kidneys. Hydroxyurea and blood transfusions are two approaches that may limit such damage.

Author: Jones, Laurie
Publisher: American College of Physicians
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
Care and treatment, Sickle cell anemia

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COX-2 inhibitors: Is there cause for concern?

Article Abstract:

Whether there is or is not cause for concern relative to the cyclooxygenase 2 (COX-2) inhibitors is discussed. A study has shown reasons for investigation into both risks and benefits to continue. The putative anti-inflammatory role of COX-2 and some prostaglandins may be in reality a pro-proliferative response of cells at the site of inflammation.

Author: Seibert, Karen, Lefkowith, James, Tripp, Catherine, Isakson, Peter, Needleman, Philip
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
United States, Evaluation, Physiological aspects, COX-2 inhibitors, Anti-inflammatory drugs, Anti-inflammatory agents

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