Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast

Article Abstract:

Aspirin appears to act differently at the cellular level in placenta tissue than it does in other human tissue. These mechanisms may alter how researchers view aspirin's role in preventing preeclampsia. The effects of aspirin on prostaglandin expression were evaluated in placenta tissue samples from 15 uncomplicated deliveries. There was a significant rise in prostaglandin H synthase-1 expression, a slight rise in prostaglandin H synthase-2 expression, and a decrease in 15-hydroxyeicosatetraenoic acid in cells treated with aspirin. Thromboxane B2 and prostaglandin E2 expression also decreased with aspirin treatment.

Prostaglandins, Aspirin, Trophoblast, Trophoblasts

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The release of 15-hydroxyeicosatetraenoic acid by human placental trophoblast is increased in preeclampsia

Article Abstract:

A chemical in the body called 15-hydroxyeicosatetraenoic acid is produced in greater quantities during preeclampsia. Preeclampsia is a complication of pregnancy characterized by hypertension and protein in the urine. Researchers measured the amount of 15-hydroxyeicosatetraenoic acid produced by placental cells taken from 10 women with normal pregnancies and five with pregnancies complicated by preeclampsia. Levels of 15-hydroxyeicosatetraenoic acid were up to five times higher in women with preeclampsia. These levels could damage blood vessels, which is common in women with preeclampsia.

Preeclampsia, Eicosanoic acid

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Hypoxia limits differentiation and up-regulates expression and activity of prostaglandin H synthase 2 in cultured trophoblast from term human placenta

Article Abstract:

Hypoxia appears to inhibit the development of placental tissues and this inhibition involves prostaglandin H. Hypoxia is low levels of oxygen in tissues. Researchers took samples of placenta tissue and cultured the samples under low oxygen levels. This inhibited the development of immature placental cells. It also increased expression of an enzyme that produces prostaglandin H as well as prostaglandin E2 and thromboxane. Preeclampsia and fetal growth retardation both involve low oxygen levels.

Hypoxia, Anoxia, Cell differentiation

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