Assessing understanding for HIV vaccine trial participation in South Africa
Article Abstract:
Detailed operational scoring criteria study was used to design and compare 4 alternative measures of understanding for potential participants being prepared for enrollment in South African HIV vaccine trials. It is concluded that levels of measured understanding are dependent on the tools used and consideration should be given to complementing checklist and self-reports with open-ended measures, particularly for critical trial concepts where the consequences of misunderstanding are potentially severe.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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Novel approach for differential diagnosis of HIV infections in the face of vaccine-generated antibodies: Utility for detection of diverse HIV-1 subtypes
Article Abstract:
A new HIV serodetection assay, the HIV-SELECTEST, was established that distinguishes between vaccine-induced antibodies seroconversion due to true HIV infections. A study examined the reactivity of plasma samples from >3000 infections with diverse HIV subtypes worldwide and it is felt that HIV-SELECTEST can be an important differential diagnostic tool for HIV vaccine trials, population screening all over the world and blood banks.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
An adenovirus-based HIV subtype B prime/boost vaccine regimen elicits antibodies mediating broad antibody-dependent cellular cytotoxicity against non-subtype B HIV strains
Article Abstract:
HIV subtype B that predominates North America and a study on ten chimpanzees regarding this protein in MF59 adjuvant is discussed. The study shows that HIV subtype B recombinant prime/envelope protein boost regimen was a good approach for eliciting broad antibody-dependent cellular cytotoxicity activity against HIV clades of diverse types.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
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