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Association of an HLA-DQ allele with clinical tuberculosis

Article Abstract:

A gene may be associated with increased risk of developing tuberculosis (TB). Researchers studied genes thought to be related to TB susceptibility in 126 patients with TB and 88 healthy people in Cambodia. TB causes significant illness and death in Cambodia, and many people are exposed to the infectious bacteria. A variant of a human leukocyte antigen histocompatibility complex was discovered in 12% of TB patients and none of the healthy patients. This genetic variation may affect the immune system response to exposure to mycobacteria and influence the progression of TB.

Author: Yunis, Edmond J., Cohen, Carol, Goldfeld, Anne E., Delgado, Julio C., Sok Thim, Bozon, M. Viviana, Uglialoro, Adele M., Turbay, David
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
Health aspects, Diseases, Genetic aspects, Tuberculosis, Mycobacterium tuberculosis, HLA histocompatibility antigens, HLA antigens, Cambodians

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Asthma linked to psychiatric disorders

Article Abstract:

The increased risk of asthmatic patients manifesting psychiatric problems including posttraumatic stress disorder (PSTD) is discussed.

Author: Keuhn, Bridget M.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2008
United States, Psychological aspects, Risk factors, Asthma, Anxiety, Depression in adolescence, Adolescent depression

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