Screening for unruptured intracranial aneurysms in autosomal dominant polycystic kidney disease

Article Abstract:

Patients with polycystic kidney disease may have a higher risk of developing intracranial aneurysms (bulging in arteries in the head) than other patients. Polycystic kidney disease is a genetic disorder that affects multiple organs including the kidneys, heart and gastrointestinal tract. A research study found that 4% of young patients with polycystic kidney disease had an intracranial aneurysm, which is a higher rate than among the general population. The number of aneurysms among these patients may be even higher than calculated because small aneurysms are difficult to detect. This study also found that patients with polycystic kidney disease were more likely to experience reversible complications after undergoing angiography. Patients with a family history of intracranial aneurysms may have a higher risk of developing aneurysms than others. Patients with polycystic kidney disease may benefit from routine screening for intracranial aneurysms.

Causes of, Complications and side effects, Polycystic kidney disease, Intracranial aneurysms, Cerebral aneurysm

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A comparison of sustained-release bupropion and placebo for smoking cessation

Article Abstract:

The antidepressant drug bupropion may help many smokers quit. Researchers randomly assigned 615 smokers to take 100, 150, or 300 milligrams (mg) of the drug or a placebo daily for seven weeks. By the end of seven weeks, 44% of those taking 300 mg had stopped smoking, compared to 38% of those on 150 mg, 29% of those on 100 mg and 19% of those on placebo. However, one year later, many smokers had begun smoking again and abstinence rates were 23% in the 300 mg group, 23% in the 150 mg group, 20% in the 100 mg group and 12% in the placebo group. The drug reduced weight gain in ex-smokers and had few side effects.

Evaluation, Smoking cessation programs, Smoking cessation, Bupropion

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