Atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion: diagnostic criteria and management

Article Abstract:

Atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions present a diagnostic dilemma. These findings form a catch-all diagnosis identifying Pap smear results that are not unequivocally normal. The diagnosis encompasses degenerating normal cells, inflamed or healing cells, cells infected with human papilloma virus, poor slide preparation, and precancerous cells. Good communication between doctor and cytologist can help with clinical decision making. Frequent regular repeat Pap smears can establish whether the condition is harmless and disappears, responds to antibiotics or hormonal therapy, or represents precancerous changes.

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Loop excision for high-grade squamous intraepithelial lesion on cytology: correlation with colposcopic and histologic findings

Article Abstract:

Women whose Pap smear shows high-grade squamous intraepithelial lesions should have a therapeutic procedure called loop electrosurgical excision of the cervix (LEEP) even if they don't have a cervical biopsy, according to a study of 104 women. None of the women had a cervical biopsy, but LEEP found that 61% had a precancerous condition called cervical intraepithelial neoplasia (CIN).

Evaluation, Excision (Surgery)

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Clinical significance of the qualification of atypical squamous cells of undetermined significance: an analysis on the basis or histologic diagnoses

Article Abstract:

Atypical squamous cells of undetermined significance (ASCUS) suggestive of an intraepithelial lesion are more likely to develop into an intraepithelial lesion than ASCUS suggestive of a reactive process. ASCUS is an abnormality of the cervix usually found on a Pap smear that is not cancerous.

Medical examination, Physiological aspects, Cervix uteri

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