Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis

Article Abstract:

Three patients with rheumatoid arthritis, a disease causing inflammation and stiffness in the joints, were treated with an antibody extracted from rats that attacks T lymphocytes, a type of active disease-fighting white blood cell. Two patients responded well for about three months, and there were no significant side effects. This suggests that T lymphocytes play a key role in the mechanism of rheumatoid arthritis. Treatment could not be continued because of the risk of causing the patients' immune systems to attack the injected rat antibodies. Versions of these antibodies, altered so as to resemble human antibodies, could possibly be developed.

Physiological aspects, T cells, Monoclonal antibodies

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Importance of synovial fluid aspiration when injecting intra-articular corticosteroids

Article Abstract:

Doctors should remove some fluid from the joints of rheumatoid arthritis patients before injecting the joint with corticosteroids. In a study of 147 RA patients, those who had fluid removed before the injection were less likely to have a relapse.

Corticosteroids, Adrenocortical hormones, Injections, Hypodermic, Subcutaneous injections

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p53 expression in rheumatoid and psoriatic arthritis synovial tissue and association with joint damage

Article Abstract:

Methods to detect p53 protein in synovial tissue of patients with rheumatoid arthritis and in patients with psoriatic arthritis are examined.

Spain, Psoriatic arthritis

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