Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo

Article Abstract:

T cell activation via the complex of interleukin-6 with its soluble receptor seems to cause the chronic intestinal inflammation in patients with Crohn disease. Blocking this reaction could make mucosal T-cells susceptible to apoptosis.

Crohn's disease, Interleukin-6

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New feelings about the role of sensory nerves in inflammation

Article Abstract:

A cell receptor on sensory nerves called proteinase-activated receptor 2 (PAR2) is stimulated by trypsin and tryptase. Once stimulated, PAR2 causes the nerve to release neuropeptides that mediate neurogenic inflammation.

Research, Sensory receptors, Trypsin

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Protection from septic shock by neutralization of macrophage migration inhibitory factor

Article Abstract:

Drugs that inhibit macrophage migratory inhibitory factor (MIF) could prevent sepsis. In mice, an anti-MIF antibody protected the mice from sepsis even when given 8 hours after the induction of peritonitis.

Prevention, Macrophages, Septic shock

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