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Bone marrow spawns brain killers

Article Abstract:

Ischemic stroke, a devastating brain disease, is caused by sudden occlusion of cerebral artery that cuts off the blood supply to a restricted region of the brain and thus resulting in death. Studies in mice show that activation of an adenosine receptor on neutrophils invading the brain from the blood contributes to the brain damage.

Author: Iadecola, Costantino
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004

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Role of matrix metalloproteinases in delayed cortical responses after stroke

Article Abstract:

A study to show that the matrix metalloproteinases (MMPs) participate in delayed cortical response after focal cerebral ischemia in rats was conducted. The data suggest that contrary to MMP inhibitor therapies for acute stroke, strategies that modulate MMPs may be needed for promoting stroke recovery.

Author: Mooney, David J., Bing-Qiao Zhao, Sophia Wang, Xiaoying Wang, Hahn-Young Kim, Eng H. Lo, Storrie, Hannah, Rosen, Bruce R.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
Care and treatment, Cerebral ischemia, Matrix metalloproteinase inhibitors

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Donor APCs are required for maximal GVHD but not for GVL

Article Abstract:

An attempt is made to show that graft-versus-host disease (GVHD) develops in recipients of donor major histocompatibility complex class I-deficient (MHC I -) bone marrow. Studies identify that donor APCs as a new target for treating GVHD, which may preserve graft-versus-leukemia (GVL).

Author: Jain, Dhanpat, Matte, Catherine C., Cormier, James, Athanasiadis, Ioanna, McNiff, Jennifer, Shlomchik, Warren D., Jinli Liu, Anderson, Britt E.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Adenoviruses, Human, Human adenoviruses

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Subjects list: Research, United States, Stroke (Disease), Stroke, Bone marrow
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