Brief report: A single neoplastic clone in sequential biopsy specimens from a patient with primary gastric-mucosa-associated lymphoid-tissue lymphoma and Sjogren's syndrome

Article Abstract:

Mucosa-associated lymphoid-tissue (MALT) lymphomas appear to progress slowly through the body with no apparent change in the genetic makeup of the cancerous cells. A 79-year-old woman with dry mouth was diagnosed with Sjogren's syndrome after a lip biopsy. Two years later, a biopsy of stomach tissue revealed that she had low-grade B-cell MALT lymphoma. Researchers examined tissue samples from her stomach and bone marrow, and compared them with the two-year-old lip sample and also with stomach tissue that had been removed during ulcer surgery 13 years previously. The polymerase chain reaction (PCR) was used to analyze DNA from the different tissue samples and this analysis showed involvement of genetically identical cancerous B cells.

Physiological aspects, Sjogren's syndrome

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Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells

Article Abstract:

The lymphocytic and histiocytic (L&H) cells characteristic of nodular lymphocyte-predominant Hodgkin's disease appear to result from expansion of a single B cell. Researchers used the polymerase chain reaction to analyze the rearranged genes for the immunoglobulin heavy chain in tissue samples taken from 11 patients with this type of Hodgkin's disease. The L&H cells had identically rearranged genes, regardless of which part of the sample they came from. This indicates that the cells were B cells and that they all originated from one cell.

Analysis, Hodgkin's disease, Gene mutations, Gene mutation

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Bacterial infection and MALT lymphoma

Article Abstract:

A bacteria called Campylobacter jejuni may cause a type of cancer called immunoproliferative small intestinal disease. A study published in 2004 showed that antibiotics can be used successfully to treat this disease. When these patients were studied further, they were found to be infected with Campylobacter jejuni.

Health aspects, Campylobacter

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