Brief report: autoantibodies against erythropoietin in a patient with pure red-cell aplasia

Article Abstract:

Autoantibodies against erythropoietin may be a feature in pure red-cell aplasia, a severe form of anemia characterized by missing red blood cells in the bone marrow. Researchers identified autoantibodies blocking erythropoietin production in a severely anemic 70-year-old woman with pure red-cell aplasia in her bone marrow. Specifically, IgG antibody activity was thought to neutralize erythropoietin, causing unusually low levels of erythropoietin and hemoglobin in blood. As a result of this inability to bind erythropoietin, the patients opted to receive blood transfusions with filtered red-cell concentrates but no immunosuppressive therapy. After nine months, antibodies decreased parallel to an increase of erythropoietin levels. Transfusions became unnecessary after blood values stabilized in the absence of autoantibodies 18 months after the start of therapy.

Health aspects, Autoantibodies, Physiological aspects, Blood transfusion, Erythropoiesis, Pure red cell aplasia

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Pure red-cell aplasia and epoetin therapy

Article Abstract:

Reports of epoetin-associated pure red-cell aplasia from the Food and Drug Administration (FDA) and from the manufacturers of Eprex, Epogen and Neorecormon were obtained and analyzed. The results indicate a reduction of more than 80 percent in the incidence of pure red-cell aplasia due to Eprex.

Reports, Causes of, Dosage and administration, United States. Food and Drug Administration, Epogen (Medication), Ectodermal dysplasia, Eprex (Medication), NeoRecormon (Medication)

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Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis

Article Abstract:

Cinacalcet lowers parathyroid hormone levels and improves calcium-phosphorous homeostasis, for patients receiving hemodialysis and have uncontrolled secondary hyperparathyroidism. Treatment of secondary hyperparathyroidism in patients receiving dialysis is studied.

United States, Care and treatment, Hemodialysis patients, Hyperparathyroidism

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