CD4+ T-lymphocyte lines developed from HIV-1-seropositive patients recognize different epitopes within the V3 loop

Article Abstract:

CD4+ T cells appear to be capable of reacting to several different amino acid sequences in the variable region 3 (V3) of the gp160 glycoprotein of HIV-1. The gp160 glycoprotein plays an important role in HIV infection. Researchers developed five T cell lines specific for the gp120 and gp160 viral proteins from four HIV-infected people. They measured the response of these T cell lines to truncated forms of the V3 region that contained different sequences, or epitopes. Each T cell line was activated by different epitopes, indicating that there is a cluster of epitopes against which T cells will react. However, the T cell lines did not react against V3 regions from different viral strains.

Antigenic determinants

---

Human CD4+ T cells can discriminate the molecular and structural context of T epitopes of HIV gp120 and HIV p66

Article Abstract:

The use of T cells taken from people uninfected with HIV in research for an HIV vaccine may produce inconsistent results that cannot be translated to a person's real exposure to HIV. Researchers took T cells from people who were not infected with HIV, cloned the T cells, and exposed them to certain HIV proteins in a laboratory setting. T cells produced immune responses to certain HIV proteins in some contexts but not in others. These results may be quite different from the reaction of T cells to whole HIV in a human body. HIV peptides should not be included in vaccine experiments until their reactivity with proteins and virus particles is analyzed.

AIDS vaccines

---

Natural analogue peptides of an HIV-1 GP120 T-helper epitope antagonize response of GP120-specific human CD4 T-cell clones

Article Abstract:

HIV can create gene mutations that allow it to evade the immune system. These gene mutations arise because the enzyme reverse transcriptase is not completely accurate.

HIV (Viruses), HIV, Genetic aspects

Similar abstracts:

• Abstracts: CD4+ lymphocyte count in African patients co-infected with HIV and tuberculosis. Characterization of conformation and dynamics of CD4 fragment (81-92) TYICEVEDQKEE and its benzylated derivative by 1H NMR spectroscopy and molecular modeling: relevance of conformation to biological function
• Abstracts: Correcting misconceptions about oral contraceptives. The patient's reaction to side effects of oral contraceptives
• Abstracts: Pathologists request autopsy revival. "Bill of Rights" for patients sent to Clinton. Put human cloning on hold, say bioethicists
• Abstracts: Automated telephone screening survey for depression. Psychotropic Drug Use in Very Young Children. A 52-Year-Old Suicidal Man
• Abstracts: Poor show: the latest DoH report on health across the UK shows clearly that poor people experience more ill health than the better off

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.